SLC26A6 (PAT1)-selective inhibitor identified in a small molecule screen blocks fluid absorption in small intestine.

 Cil O, Haggie PM, Tan JAT, Rivera AA, Verkman AS. JCI Insight 2021 

Small Molecule Inhibitor of Chloride Channel TMEM16A Blocks Vascular Smooth MuscleContraction and Lowers Blood Pressure in Spontaneously Hypertensive Rats.

Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS. Kidney Int. 2021 

Repurposing calcium sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas

Oak AA, Chhetri PD, Rivera AA, Verkman AS, Cil O. JCI Insight. 2021

a-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.Hypertension. 2020 Sep 1

Cil O, Perwad F. Pediatrics. 2020

4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.​

 Lee S, Cil O, Haggie PM, Verkman AS. J Med Chem. 2019

Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.

Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. FASEB J. 2019

Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.

 Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. FASEB J. 2019

Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.

Duan T, Cil O, Thiagarajah JR, Verkman AS. JCI Insight. 2019

SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.

Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. JCI Insight. 2018

Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.

 Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. J Med Chem. 2018

Monogenic Causes of Proteinuria in Children.

Cil O, Perwad F. Front Med. 2018

Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).

 Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. J Med Chem. 2017

High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.

 Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. J Med Chem. 2017

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.

Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. FASEB J. 2017

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.

Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS.Transl Res. 2017

Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.

Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS.J Am Soc Nephrol. 2016

CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.

Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. Cell Mol Gastroenterol Hepatol. 2016

A Turkish BCS1L mutation causes GRACILE-like disorder.

Serdaroglu E, Takci S, Kotarsky H, Çil O, Utine E, Yigit S, Fellman V. Turk J Pediatr. 2016

MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis.

Besbas N, Kalyoncu M, Cil O, Ozgul RK, Bakkaloglu A, Ozaltin F. Ren Fail. 2015

Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.

Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. Kidney Int. 2015

Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome.

Cil O, Besbas N, Duzova A, Topaloglu R, Peco-Antic A, Korkmaz E, Ozaltin F. Pediatr Nephrol. 2015

Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.

Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. FASEB J. 2014

Small-molecule inhibitors of urea transporters.  

Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. Subcell Biochem. 2014

A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period.

Unal S, Gumruk F, Yigit S, Tuncer M, Tavil B, Cil O, Takci S, Urata M, Hotta T, Kang D, Cetin M. Pediatr Blood Cancer. 2014

Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.

Celebi N, Cil H, Cil O, Canbay O, Onur R, Aypar U. Neurosciences. 2013

Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.

Ozaltin F, Besbas N, Iskit AB, Cil O, Akcoren Z, Kale G, Bakkaloglu A. Ren Fail. 2013

The diuretic effect of urea analog dimethylthiourea in female Wistar rats.

Cil O, Ertunc M, Onur R. Hum Exp Toxicol. 2012

Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical.

 Cil O, Ertunc M, Gucer KS, Ozaltin F, Iskit AB, Onur R. Ren Fail. 2012

Family history of renal disease severity predicts the mutated gene in ADPKD.

 Barua M, Cil O, Paterson AD, Wang K, He N, Dicks E, Parfrey P, Pei Y. J Am Soc Nephrol. 2009

Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease.

Wang K, Zhao X, Chan S, Cil O, He N, Song X, Paterson AD, Pei Y. Clin J Am Soc Nephrol. 2009