Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria.
Ahmadi M, de Souza Goncalves L, Verkman AS, Cil O, Anderson MO. RSC Med Chem. 2024
Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody–Drug Conjugates (ADCs).
Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PL, Lu J, Esserman LJ, Parsicha ND. Current Ophthalmology Reports. 2024
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
de Souza Goncalves L, Chu QT, Master R, Chhetri PD, Gao Q and Cil O. J Clin Invest. 2024
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment.
Yottasan P, Chu T, Chhetri PD and Cil O. Transl Res. 2024
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas.
Chu T, Yottasan P, de Souza Goncalves L, Oak AA, Lin R, Tse M, Donowitz M and Cil O. Transl Res. 2024
Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.
Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO and Cil O. RSC Med Chem. 2023
Structure of human NCC: insights into the inhibition mechanism of thiazides.
de Souza Goncalves L, Yottasan P and Cil O. Signal Transduct Target Ther. 2023
Case report: Short-term eculizumab use in atypical HUS associated with Lemierre's syndrome and post-infectious glomerulonephritis.
Sadiq S, Urisman A and Cil O. Front Med. 2023
Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.
Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS. Eur J Med Chem. 2023
Genetic testing in children with nephrolithiasis and nephrocalcinosis.
Gefen AM, Sethna CB, Cil O, Perwad F, Schoettler M, Michael M, Angelo JR, Safdar A, Amlie-Wolf L, Hunley TE, Ellison JS, Feig D, Zaritsky JJ. Pediatr Nephrol. 2023
Ocular surface ion transport and dry eye disease.
Lindgren ES, Cil O, Verkman AS, Pasricha ND. Current Ophthalmology Reports. 2022
Lubiprostone is non-selective activator of cAMP-gated ion channels and Clc-2 has a minor role in its prosecretory effect in intestinal epithelial cells.
Oak AA, Chu QT, Yottasan P, Chhetri PD, Zhu J, Du Bois J, Cil O. Mol Pharmacol. 2022
Cystinuria: an overview of diagnosis and medical management.
Sadiq S, Cil O. Turk Arch Pediatr. 2022
Small molecule inhibitor of intestinal anion exchanger SLC26A3 for therapy of hyperoxaluria and nephrolithiasis.
Cil O, Chu QT, Lee S, Haggie PM, Verkman AS. JCI Insight. 2022
SLC26A6 (PAT1)-selective inhibitor identified in a small molecule screen blocks fluid absorption in small intestine.
Cil O, Haggie PM, Tan JAT, Rivera AA, Verkman AS. JCI Insight. 2021
Small molecule inhibitor of chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.
Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS. Kidney Int. 2021
Repurposing calcium sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas
Oak AA, Chhetri PD, Rivera AA, Verkman AS, Cil O. JCI Insight. 2021
a-Lipoic Acid (ALA) improves cystine solubility in cystinuria: report of 2 cases.
Cil O, Perwad F. Pediatrics. 2020
4,8-Dimethylcoumarin inhibitors of intestinal anion exchanger slc26a3 (downregulated in adenoma) for anti-absorptive therapy of constipation.
Lee S, Cil O, Haggie PM, Verkman AS. J Med Chem. 2019
Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.
Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. FASEB J. 2019
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. FASEB J. 2019
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.
Duan T, Cil O, Thiagarajah JR, Verkman AS. JCI Insight. 2019
SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. JCI Insight. 2018
Nanomolar-potency 1,2,4-triazoloquinoxaline inhibitors of the kidney urea transporter UT-A1.
Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. J Med Chem. 2018
Monogenic causes of proteinuria in children.
Cil O, Perwad F. Front Med. 2018
Substituted 2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A).
Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. J Med Chem. 2017
High-potency phenylquinoxalinone cystic fibrosis transmembrane conductance regulator (CFTR) activators.
Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. J Med Chem. 2017
Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. FASEB J. 2017
Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS.Transl Res. 2017
Small-molecule inhibitors of pendrin potentiate the diuretic action of furosemide.
Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS.J Am Soc Nephrol. 2016
CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.
Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. Cell Mol Gastroenterol Hepatol. 2016
A Turkish BCS1L mutation causes GRACILE-like disorder.
Serdaroglu E, Takci S, Kotarsky H, Çil O, Utine E, Yigit S, Fellman V. Turk J Pediatr. 2016
MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis.
Besbas N, Kalyoncu M, Cil O, Ozgul RK, Bakkaloglu A, Ozaltin F. Ren Fail. 2015
Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.
Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. Kidney Int. 2015
Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome.
Cil O, Besbas N, Duzova A, Topaloglu R, Peco-Antic A, Korkmaz E, Ozaltin F. Pediatr Nephrol. 2015
Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.
Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. FASEB J. 2014
Small-molecule inhibitors of urea transporters.
Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. Subcell Biochem. 2014
A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period.
Unal S, Gumruk F, Yigit S, Tuncer M, Tavil B, Cil O, Takci S, Urata M, Hotta T, Kang D, Cetin M. Pediatr Blood Cancer. 2014
Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.
Celebi N, Cil H, Cil O, Canbay O, Onur R, Aypar U. Neurosciences. 2013
Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.
Ozaltin F, Besbas N, Iskit AB, Cil O, Akcoren Z, Kale G, Bakkaloglu A. Ren Fail. 2013
The diuretic effect of urea analog dimethylthiourea in female Wistar rats.
Cil O, Ertunc M, Onur R. Hum Exp Toxicol. 2012
Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical.
Cil O, Ertunc M, Gucer KS, Ozaltin F, Iskit AB, Onur R. Ren Fail. 2012
Family history of renal disease severity predicts the mutated gene in ADPKD.
Barua M, Cil O, Paterson AD, Wang K, He N, Dicks E, Parfrey P, Pei Y. J Am Soc Nephrol. 2009
Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease.
Wang K, Zhao X, Chan S, Cil O, He N, Song X, Paterson AD, Pei Y. Clin J Am Soc Nephrol. 2009